NSF Org:	EFMA Office of Emerging Frontiers in Research and Innovation (EFRI)
Recipient:	REGENTS OF THE UNIVERSITY OF MICHIGAN
Initial Amendment Date:	August 29, 2024
Latest Amendment Date:	August 29, 2024
Award Number:	2422149
Award Instrument:	Continuing Grant
Program Manager:	Steve Zehnder szehnder@nsf.gov  (703)292-7014 EFMA  Office of Emerging Frontiers in Research and Innovation (EFRI) ENG  Directorate for Engineering
Start Date:	September 1, 2024
End Date:	August 31, 2028 (Estimated)
Total Intended Award Amount:	$1,999,997.00
Total Awarded Amount to Date:	$1,489,183.00
Funds Obligated to Date:	FY 2024 = $1,489,183.00
History of Investigator:	Jianping Fu (Principal Investigator) jpfu@umich.edu Feng Guo (Co-Principal Investigator) Insoo Hyun (Co-Principal Investigator)
Recipient Sponsored Research Office:	Regents of the University of Michigan - Ann Arbor 1109 GEDDES AVE STE 3300 ANN ARBOR MI  US  48109-1015 (734)763-6438
Sponsor Congressional District:	06
Primary Place of Performance:	Regents of the University of Michigan - Ann Arbor 1109 GEDDES AVE, SUITE 3300 ANN ARBOR MI  US  48109-1079
Primary Place of Performance Congressional District:	06
Unique Entity Identifier (UEI):	GNJ7BBP73WE9
Parent UEI:
NSF Program(s):	OFFICE OF MULTIDISCIPLINARY AC, DMR SHORT TERM SUPPORT, PHYSICS OF LIVING SYSTEMS, IIS Special Projects, EFRI Research Projects, Unallocated Program Costs
Primary Program Source:	01002324DB NSF RESEARCH & RELATED ACTIVIT 01002425DB NSF RESEARCH & RELATED ACTIVIT 01002526DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s):	8089
Program Element Code(s):	125300, 171200, 724600, 748400, 763300, 919900
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.041, 47.049, 47.070

ABSTRACT

The demand for powerful and energy-efficient artificial intelligence (AI) is growing rapidly. Current AI hardware, which uses silicon chips, struggles to meet these needs for advanced AI models. This Emerging Frontiers in Research and Integration (EFRI) project will develop innovative computing systems inspired by the structure and function of the human brain. Specifically, the project will create advanced human brain organoids (hBOs). These are miniature 3D models of the human brain grown from stem cells in a lab dish. They contain various types of brain cells that organize themselves into structures resembling parts of the developing human brain. hBOs can process information and perform computations in ways that parallel the human brain's capabilities. This EFRI research will integrate multiple hBOs with different arrangements and connections to develop new computing architectures that are highly efficient in terms of energy consumption and computing power. In addition, Bioethicists will collaborate closely with engineering researchers at each step of the project to study ethical considerations related to public acceptance and oversight of hBO computing.

This EFRI BEGIN OI project will develop an hBO-based biocomputing system that integrates neuromorphic computing theory, bioengineered hBOs, and critical bioethical research. It will advance theoretical concepts in biocomputing with human cortical neural networks by designing optimal neural networks and implementing adaptive learning mechanisms. The research will explore how factors like excitatory-inhibitory balanced networks, connectivity density, and network scale affect the computational capacity of hBOs. Additionally, the project will develop bioengineered multi-hBO systems with organized hBOs containing excitatory and inhibitory neuron populations in local microcircuits. These novel hBOs will interface with electronics to achieve real-time read-in and read-out of neuronal activity, leveraging the adaptive learning properties inherent in hBOs. This effort represents a critical step toward developing neuromorphic computing hardware capable of achieving superior computing power with low energy consumption. Importantly, the EFRI research will also address bioethical challenges associated with hBO-based biocomputing by refining an innovative approach to engineering ethics. It will ensure alignment with evolving standards in AI and biomedical research ethics, engaging policymakers and ethical committees to navigate the complex landscape of human biomaterial use in computing applications and fostering public trust and acceptance. Educational efforts within the EFRI project will reach diverse student populations, including K-12 and underrepresented groups, nurturing interest in STEM and biological research. Outreach activities will engage students in both the US and Israel with STEM challenges and offer interdisciplinary training opportunities for graduate students in both countries.

This project is jointly funded by the Emerging Frontiers in Research and Innovation Program (BEGIN OI), the Directorate for Computer and Information Science and Engineering, and the Directorate for Mathematical and Physical Sciences.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

Please report errors in award information by writing to: awardsearch@nsf.gov.