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Press Release 14-051
The National Science Foundation names Feng Zhang its Alan T. Waterman Awardee for 2014

Young researcher honored for early contributions, supported for even greater impact

NSF's 2014 Alan T. Waterman Awardee Feng Zhang.

NSF's 2014 Alan T. Waterman Awardee Feng Zhang.
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April 14, 2014

The National Science Foundation (NSF) named Feng Zhang the 2014 recipient of its Alan T. Waterman Award. This award is NSF's highest honor that annually recognizes an outstanding researcher under the age of 35 and funds his or her research in any field of science or engineering. Zhang's research focuses on understanding how the brain works.

"It is a great pleasure to honor Feng Zhang with this award for his young, impressive career," said NSF Director France Córdova. "It is exciting to support his continued fundamental research, which is certain to impact the field of brain research. Imagine a future free of schizophrenia, autism and other brain disorders that wreak havoc on individuals, families and society. Feng's research moves us in that direction."

Zhang seeks to understand the molecular machinery of brain cells through the development and application of innovative technologies. He created and is continuing to perfect tools that afford researchers precise control over biological activities occurring inside the cell. With these tools, researchers can deepen their understanding of how the genome works, and how it influences the development and function of the brain. Zhang also examines failures within the systems that cause disease.

Two different lines of fundamental research and technology development are helping him do that: optogenetics and genome engineering. Along with Edward Boyden and Karl Deisseroth at Stanford University, he invented a set of technologies for dissecting the functional organization of brain circuits, The successful development of optogenetics has enabled the systematic investigation of neural circuit function in vivo with unprecedented precision of control. Zhang used that approach to lead landmark studies that illuminated the neural codes for arousal, reward and circuit oscillation. He also developed light-inducible transcription effectors that enabled optogenetic control of transcription and epigenetic process in the brain and other tissues.

Zhang also improved the CRISPR system to enable new, cheaper, more effective ways to "edit" animal genomes--that is, to identify and cut a short DNA sequence underlying a disorder so that it may be deleted or substituted out for other genetic material Although Zhang's main area of focus is the brain, the potential applications of CRISPR technology extend well beyond neuroscience.

"This is an immensely exciting time for the field because of the tremendous potential of tools like CRISPR, which allows us to modify the genomes of mammalian cells," Zhang said. "One of my long-term goals is to better understand the molecular mechanisms of brain function and identify new ways to treat devastating neurological disorders."

Since high school, Zhang has devoted his time, energy and intellectual prowess to developing ways to study and repair the nervous system. Today, he is one of 11 core faculty members at the Broad Institute of MIT and Harvard; an investigator at MIT's McGovern Institute for Brain Research; and the W. M. Keck Career Development Professor with a joint appointment in MIT's Departments of Brain and Cognitive Sciences and Biological Engineering.

Zhang is widely recognized for his pioneering work in optogenetics and genome editing. He shared the Perl/UNC Neuroscience Prize with Karl Deisseroth and Edward Boyden in 2012. In 2013, MIT Technology Review recognized him as a "pioneer" and one of its 35 Innovators Under 35; Popular Science magazine placed Zhang on its Brilliant 10, an annual list of the most promising scientific innovators. Nature also named him as one of the "ten people who mattered" in 2013 for his work on developing the CRISPR system for genome editing in mammalian cells.

The Waterman award will be presented to Zhang at an evening ceremony at the U.S. Department of State in Washington, D.C., on May 6. At that event, the National Science Board will also present its 2014 Vannevar Bush award to mathematician Richard Tapia and Public Service awards to bioethicist Arthur Caplan and to the AAAS Science & Technology Policy Fellowships Program.

Plans are underway for Zhang to deliver a lecture at a meeting of the National Science Board at NSF and to meet with students at Thomas Jefferson High School for Science and Technology during his visit this spring.

-NSF-

Media Contacts
Lisa-Joy Zgorski, NSF, (703) 292-8311, lisajoy@nsf.gov
Julie Pryor, McGovern Institute for Brain Research at MIT, (617) 715-5397, jpryor@mit.edu
Haley Bridger, Broad Institute of MIT and Harvard, (617) 714-7968, hbridger@broadinstitute.org

Program Contacts
Mayra N. Montrose, NSF, (703) 292-4757, mmontros@nsf.gov

Related Websites
White House Blog: President Obama Honors the Nation's Cutting-Edge Scientists and Engineers: http://www.whitehouse.gov/blog/2014/04/15/inspiring-next-generation-innovators-president-obama-honors-nations-cutting-edge-sci
McGovern Institute for Brain Research at MIT: http://mcgovern.mit.edu/
The Broad Institute of MIT and Harvard: http://www.broadinstitute.org/
About the Alan T. Waterman Award: http://www.nsf.gov/od/waterman/waterman.jsp
Waterman Award Recipients Since 1976: http://www.nsf.gov/od/waterman/waterman_recipients.jsp
Full biography of Feng Zhang: http://www.broadinstitute.org/history-leadership/scientific-leadership/core-members/feng-zhang
Popular Science, How Feng Zhang Modified A Cell's Genome On The Fly: http://www.popsci.com/science/article/2013-09/feng-zhang
Genomic research may finally help dispel the ignorance shrouding many types of mental illness.: http://www.technologyreview.com/lists/innovators-under-35/2013/pioneer/feng-zhang/

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. In fiscal year (FY) 2014, its budget is $7.2 billion. NSF funds reach all 50 states through grants to nearly 2,000 colleges, universities and other institutions. Each year, NSF receives about 50,000 competitive requests for funding, and makes about 11,500 new funding awards. NSF also awards about $593 million in professional and service contracts yearly.

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Feng Zhang in his laboratory with graduate student Patrick Hsu.
Feng Zhang in his laboratory with graduate student Patrick Hsu.
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MIT graduate student Silvana Konermann and Feng Zhang in his lab
MIT graduate student Silvana Konermann joins Feng Zhang in his laboratory.
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Feng Zhang
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NSF's 2014 Alan T. Waterman Awardee Feng Zhang discusses his research on the brain.
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