text-only page produced automatically by LIFT Text Transcoder Skip all navigation and go to page contentSkip top navigation and go to directorate navigationSkip top navigation and go to page navigation
National Science Foundation Home National Science Foundation - Biological Sciences (BIO)
Molecular and Cellular Biosciences (MCB)
design element
MCB Home
About MCB
Funding Opportunities
Career Opportunities
Examples of Broader Impacts
Supplements & Other Opportunities
See Additional MCB Resources
View MCB Staff
BIO Organizations
Biological Infrastructure (DBI)
Environmental Biology (DEB)
Emerging Frontiers (EF)
Integrative Organismal Systems (IOS)
Molecular and Cellular Biosciences (MCB)
Proposals and Awards
Proposal and Award Policies and Procedures Guide
Proposal Preparation and Submission
bullet Grant Proposal Guide
  bullet Grants.gov Application Guide
Award and Administration
bullet Award and Administration Guide
Award Conditions
Merit Review
NSF Outreach
Policy Office
Additional MCB Resources
Career Opportunities
BIO Reports
BIO Dear Colleague Letters
Interdisciplinary Research
Merit Review
Merit Review Broader Impacts Criterion: Representative Activities
Image Credits
Other Site Features
Special Reports
Research Overviews
Multimedia Gallery
Classroom Resources
NSF-Wide Investments

Email this pagePrint this page

Genes and Genome Systems Cluster

This program has been archived.


Name Email Phone Room
Karen  C. Cone kccone@nsf.gov (703) 292-4967  655 S  
Anne  Grove agrove@nsf.gov (703) 292-5029  655 S  
Neocles  B. Leontis nleontis@nsf.gov (703) 292-7113  655 S  


PD 04-1112

Important Information for Proposers

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 16-1), is effective for proposals submitted, or due, on or after January 25, 2016. Please be advised that, depending on the specified due date, the guidelines contained in NSF 16-1 may apply to proposals submitted in response to this funding opportunity.




The Genes and Genome Systems Cluster, one of three thematic areas within the Division of Molecular and Cellular Biosciences, supports studies on the structure, function and evolution of genes and genomes in prokaryotes, eukaryotes, phages, and viruses.  Areas of interest include the following: (i) mechanisms of genome maintenance including replication, repair and recombination; (ii) nuclear and extra-nuclear inheritance, horizontal gene transfer and other mechanisms leading to diversity and novel adaptive strategies in the biosphere; (iii) genetic and epigenetic mechanisms including chromatin modification and remodeling; (iv) mechanisms and regulation of gene expression including transcription, RNA processing, translation, turnover and RNA interference; (vi) structure, function and dynamics of nucleic acids and nucleic acid-protein complexes and machines; and (vii) molecular evolution and the origin of life.  Research on multi-component genetic processes is encouraged, including projects with direct relevance to climate change and energy sustainability.  The cluster welcomes "bottom-up" synthetic biology projects and "top-down" systems biology projects that integrate computational strategies with high-throughput, comparative genome-wide approaches and other experimental strategies to investigate complex gene networks and their outputs.  The development and use of innovative in vivo and in vitro approaches, including biochemical, biophysical, computational, genetic, genomic, and metagenomic methods are encouraged, as is research at the interfaces between biology and other disciplines such as physics, chemistry, mathematics, computer science, and engineering.

Program Directors:

Karen Cone.   Epigentic regulation; Plant genetics and genomics; Gene expression mechanisms.

Neocles B. Leontis.  Structure, function and dynamics of DNA, RNA and nucleic acid-protein complexes; Ribosome structure, function and assembly; Synthetic biology; RNA processing, turnover and RNA interference; Computational biology and biophysical studies.

What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)

Map of Recent Awards Made Through This Program



Email this pagePrint this page
Back to Top of page