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Discovery
Placing Landmarks on the Genome Map

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Schematic diagram showing human chromosome 21 with a small region outlined in red.

The schematic diagram shows human chromosome 21 with a small region outlined in red. The main rectangle below is a close-up of the outlined region, showing the binding locations of three transcription factors along the chromosome.

Credit: Courtesy of Vishy Iyer


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Representation of allele-specific and non-allele-specific SNPs across the CTCF binding motif (17).

Representation of allele-specific and non-allele-specific single nucleotide polymorphisms (SNPs) across the CTCF binding motif (17). The y-axis indicates the difference between the two as a percentage of normalized total SNPs. Higher bars indicate an increased representation of allele-specific SNPs relative to other positions, which tend to occur at conserved positions.

Credit: McDaniell, R., et al. 2010. Heritable Individual-Specific and Allele-Specific Chromatin Signatures in Humans. Science 328 (5975): 235-239.


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