This report was written by the participants of the workshop and produced by Dr. Peter Kollman and Willa Crowell. The workshop was supported by the National Science Foundation through Grant No. MCB 9629868 to the University of California, San Francisco. However, any opinions, findings, conclusions, or recommendations expressed herein are those of the authors and do not necessarily reflect the views of NSF.
The oncogene protein H-Ras casts a shadow on a pattern from the Game of Life, symbolic of the interdependence of multiple levels within biological systems. The structure of truncated Harvey-Ras protein complexed with a guanosine triphosphate analog was solved by Krengel, Scheffzek, Kabsch, Wittinghofer, and Pai (Brookhaven Protein Databank reference 121P). The molecules were rendered with the MidasPlus program from the Computer Graphics Laboratory (CGL, supported by NIH RR-01081), University of California, San Francisco. The background pattern is from John Conway's Game of Life cellular automaton, as implemented by Gil Rivlis, University of Arizona. Cover design and creation by Elaine Meng with assistance from other CGL members.
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