Year 1998 Awards
Minority Postdoctoral Research Fellowships
||Research Area/Training Plan
||NSF Award #|
|Title of Research and Training Plan|
||University of California-Berkeley
|"The effects of currents
and larval dispersal period on the genetic structure and evolution of
Indonesian stomatopod populations"
|Molecular genetic techniques
are being used to compare patterns of gene flow and genetic structuring
in Indonesian stomatopods with similar/different larval periods, across
regions with unidirectional and circular currents. Comparisons will be
made in a phylogenetic context to determine the effects of dispersal period,
currents, and evolutionary ancestry on the genetic structuring and evolution
of stomatopod populations.
|Jose de la Torre, III
||University of California, Berkeley
||Biotic Surveys & Inventories
carbonate deposits identified with ribosomal RNA gene sequences amplified
directly from environmental samples"
|Using PCR, microbial 16S ribosomal
RNA genes are being amplified from environmental samples from carbonate
deposits. Phylogenetic analysis of these rRNA sequences is being used
to determine the evolutionary relationships of the principal constituents
of these communities with known organisms. Hybridization probes will be
developed to determine the morphology, abundance and distribution of selected
organisms in situ.
|"Can parasites explain
the maintenance of sexual recombination?"
|Theoretical models suggest
that sexual recombination is advantageous because it breaks gene associations
fixed by past selection, allowing organisms to adapt to their present
environment. This project investigates if parasite selection causes gene
associations, whether sexual recombination increases resistance to parasites,
and whether different parasites select for similar or different host genotypes.
This research can help determine the importance of genetic diversity to
coevolution and the development of agricultural and conservation policies.
||University of Pennsylvania
||Intergrated Plant Biology
in plant development: determining function in vivo by identifying interacting
proteins, regulatory targets, and localization"
|The HOOKLESS1 acetyltransferase
is the first such enzyme to be identified in the genetically tractable
organism Arabidopsis thaliana. Acetyltransferases have many diverse functions
in prokaryotes and eukaryotes, from hormone synthesis and drug detoxification,
to transcriptional regulation and chromatin remodeling. Plants lacking
HOOKLESS1 show developmental abnormalities, providing an opportunity to
determine how an acetyltransferase regulates growth patterns in higher
||University of Vermont
|| Animal Physiology
"Regulation of arterial diameter by subcellular calcium release events"
|Local calcium release events
("calcium sparks") through ryanodine receptors in the sarcoplasmic
reticulum (SR) of vascular smooth muscle indirectly cause arterial dilation
by activating calcium- sensitive potassium (Kca) channels. Activation
of Kca channels causes hyperpolarization, closing voltage-dependent calcium
channels and thereby decreasing global cellular calcium, which causes
vasodilation. The goal of this research is to examine how the SR protein
phospholamban, by regulating SR calcium, modulates calcium sparks, membrane
voltage and diameter of myogenic arteries.
||University of California-Berkeley
|"Ecological and genetic
dissection of social behavior in the mound building mouse"
|A breeding colony of Mus spicilegus
is being established to make it possible to study the inheritance of behavior
in this and related species. Field work is being conducted to study the
ecological and social components of the behaviors under study.
||University of Massachusetts
|"Analysis of cytoplasmic
dynein light intermediate chains"
|Cytoplasmic dynein is a minus-end
directed microtubule motor complex that has been implicated in a wide
array of cellular processes including retrograde axonal transport, centripetal
organelle transport, chromosome movement and spindle organization during
mitosis. This project is a study of the role of the light intermediate
chain subunits of cytoplasmic dynein in the regulation and targeting of
this motor protein.
||National Institutes of Health
|"Determining the structure
of modular proteins in solution"
|Many of the processes inside
the cell are activated by signals outside the cell and are regulated by
proteins comprised of modules. The modules differ in their structures
and functions. By varying the type, number, and order of modules as well
as the property of the linkers that connect them, a diverse set of proteins
can be constructed. Determining the structure of modular proteins in solution
by NMR spectroscopy remains a challenge. This research uses an approach
that may facilitate structural studies of these types of proteins. It
provides a direct measurement of bond angles and distances between atoms
in a coordinate system that applies to the whole protein, promising to
aid in structure determination of the modular protein.
|Edgardo T. Farinas
to order: construction of iron containing proteins with tunable redox
|This research involves the
de novo design and synthesis of novel iron-binding sites into the protein
scaffold of known proteins that are normally devoid of transition metals.
This permits study of how reduction potential is modulated in a protein
environment. The sites are modeled after the iron-sulfur center of the
electron transfer protein rubredoxin.
|"Analysis of cell polarity
using budding yeast as a model system"
|Budding yeast undergoes polarized
cell growth during budding and mating. The MAP kinase Slt2p plays an important
role in both of these processes. The aim of these studies is to identify
and characterize targets of Slt2p and to understand the molecular mechanisms
controlling cellular morphogenesis in yeast and other eukaryotes.
Minority Graduate Student Travel
||University of Texas - Medical
||New York Medical College Valhalla,
Minority Postdoctoral Research
Fellowship Third Year Extensions