Year 1997 Awards
Minority Postdoctoral Research Fellowships
||Research Area/Training Plan
||NSF Award #|
|Title of Research and Training Plan|
||University of California-Berkely
||Intregrated Plant Biology
characterization of genes required for plant disease resistance"
|The signal transduction pathway
for plant disease resistance links pathogen recognition to increased expression
of defense genes. The goal of this research is to isolate components linking
the events of disease resistance in Arabidopsis thaliana resistant to
Pseudomonas syringae mediated by the pathogen avrRpt2. The disease resistance
response is being characterized in isolated mutants and the novel genes
involved are being cloned.
||University of Connecticut
and patterns of speciation in soil inhabiting microarthropods"
|The organisms being studied
comprise the Lepidocyrtus-Pseudosinella genera complex (Hexapoda: Collembola)
in greater Puerto Rico. Collembola are the most diverse of the primitive,
wingless hexapods and important to soil biology. Diversity and patterns
of speciation are being determined with the use of molecular tools and
geographical distribution to gain insight into the factors contributing
to the evolutionary success of this important and under-studied group
|"Biosynthesis and resistance
mechanisms of the antibiotic bacitracin"
|The goal is to elucidate the
mechanisms of biosynthesis and resistance using various methods of enzymology.
Bacitracin is a non-ribosomal cyclic polypeptide that prevents peptidoglycan
formation in bacteria. A focal point of this study is to define the role
of 4'-phosphopantetheine (4'-PP) in the peptidyl-carrier protein, bacitracin
||University of California-Irvine
||Ecology & Evolutionary
|"Fluid dynamics and
functional morphology of pectoral fins during swimming in benthic and
|The classical model of shark
locomotion is being tested, and pectoral fin function during swimming
evaluated in sharks. Comparative ecomorphology of sharks is analyzed using
fluid dynamics, kinematics, and motor pattern. The integration of functional
morphology, performance (fluid flow), and ecology (realized niche) is
necessary to accurately interpret the ecological role and evolution of
||Woods Hole Oceanographic Institution
|| Animal Behavior
|"An experimental technique
for testing if dolphin whistles are used as names"
|Bottlenose dolphins produce
individually distinctive "signature" whistles. Previous research
has assumed that these whistles function to broadcast individual identity;
but it has not been tested whether signature whistles actually label individuals,
that is, serve as referential names. This research develops a technique
for testing whether dolphins can identify other individual dolphins on
the basis of their signature whistles.
||Dartmouth Medical School
|"Functional role of
a neurotransmitter system in sex-specific reproductive behaviors"
|Differences in neuronal organization
and function in the brains of males and females provide the basis for
sexually dimorphic behaviors. Benzodiazepine modulation of GABA-mediated
currents are being determined in sexually dimorphic regions of the rat
brain. The impacts of these currents on sex-specific reproductive behaviors
mediated by these brain regions are also being studied.
|"Analysis of a conserved
DNA replication protein"
|The specific objective is to
characterize the molecular function and cellular localization of fission
yeast Cdc 19 protein. This protein is an essential, conserved eukaryotic
DNA replication protein. Interacting gene products will be identified
by genetic screens and subsequently characterized to describe the role
of Cdc 19 in DNA replication.
||University of Miami
tyrosine phosphatases in neuronal differentiation"
|Enzymes that remove phosphate
groups from signaling proteins, protein tyrosine phosphatases (PTPases),
regulate numerous aspects of cell growth and differentiation. This research
examines the role of 2 PTPases, SHP-2 and CRYP-2, in the differentiation
of developing nerve cells. Specific functions of these enzymes are being
studied using transgenic mice.
|Lino Gonzalez, Jr.
structure determination of protein complexes integral to membrane fusion"
|Membrane trafficking and fusion
are essential processes in all eukaryotic cells. The molecular machinery
mediating vesicle trafficking and fusion has been highly conserved from
yeasts to mammals, demonstrating the universal importance of the process.
In nerve terminals, nuerotransmitter-filled synaptic vesicles are docked
at the presynaptic membrane where calcium ion uptake triggers vesicle
fusion and neurotransmitter release. The complex of proteins mediating
the membrane fusion event contains proteins known as SNARE and SNAP and
other factors. This research investigates the mechanism of SNARE/SNAP
protein-protein interaction by x-ray crystallography. Protein crystals
are being obtained using a "minimalist" approach: essential
interacting domains are determined, isolated, crystallized, and structurally
Minority Graduate Student Travel
|James J. Gelsleicherter
||Mote Marine Laboratory
|Gregory M. Colores
University of Idaho
University of California, Santa Cruz
Minority Postdoctoral Research
Fellowship Third Year Extensions