Award Abstract # 0349712
SBIR Phase II: Innovative Protein Microarrays

NSF Org: TI
Translational Impacts
Recipient:
Initial Amendment Date: February 5, 2004
Latest Amendment Date: July 10, 2006
Award Number: 0349712
Award Instrument: Standard Grant
Program Manager: F.C. Thomas Allnutt
TI
 Translational Impacts
TIP
 Directorate for Technology, Innovation, and Partnerships
Start Date: February 1, 2004
End Date: January 31, 2008 (Estimated)
Total Intended Award Amount: $499,807.00
Total Awarded Amount to Date: $974,421.00
Funds Obligated to Date: FY 2004 = $499,807.00
FY 2006 = $474,614.00
History of Investigator:
  • Andrzej Drukier (Principal Investigator)
    adrukier@gmail.com
Recipient Sponsored Research Office: BioTraces Inc
13455 SUNRISE DR
HERNDON
VA  US  20171-3296
(703)793-1550
Sponsor Congressional District: 11
Primary Place of Performance: BioTraces Inc
13455 SUNRISE DR
HERNDON
VA  US  20171-3296
Primary Place of Performance
Congressional District:
11
Unique Entity Identifier (UEI):
Parent UEI:
NSF Program(s): SBIR Phase II
Primary Program Source: app-0104 
app-0106 
Program Reference Code(s): 9181, BIOT
Program Element Code(s): 537300
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.084

ABSTRACT

0349712
Drukier

This Small Business Innovation Research Phase II project proposes to develop a novel supersensitive multiphoton detection system for protein chips (P-chip/MPD) for applications in drug discovery and in early detection of prostate cancer and breast cancer.

The commercial impact of the proposed work will be in the area of diagnostic proteomics. The diagnostics industry is large, currently estimated at around 10 billion dollars per year. The most profitable and dynamically growing fields are those that permit early detection of cancer and therapy monitoring, or provide toxicity assays for new drugs. It is expected that the P-Chips/MPD developed in this project will eventually capture a significant share of the diagnostic proteomics market.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Andrzej K. Drukier,Ivan Grigoriev, Larry R. Brown, John E. Tomaszewski, Richard Sainsbury, and Jasminka Godovac-Zimmermann "Looking for Thom?s Biomarkers with Proteomics" Journal of Proteome Research , v.5 , 2006 , p.2046
Andrzej K. Drukier,Natascha Ossetrova, Elena Schors, Larry R. Brown, John Tomaszewski,Richard Sainsbury, and Jasminka Godovac-Zimmermann "Ultra-Sensitive Immunoassays Using Multi-Photon-Detection in Diagnostic Proteomics of Blood" Journal of Proteome Research , v.4 , 2005 , p.2375
Andrzej K. Drukier, Nathasha Ossetrova, Elena Schors, Galya Krasik, Ivan Grigoriev, Christina Koenig, Miko Sulkowski, Jerzy Holcman, Larry R. Brown, John E. Tomaszewski, Mitchell D. Schnall, Richard Sainsbury, Anne E. Lokshin, and Jasminka Godovac-Zimmerm "High-Sensitivity Blood-Based Detection of Breast Cancer by Multi Photon Detection Diagnostic Proteomics" Journal of Proteome Research , v.5 , 2006 , p.1906
Anna E. Lokshin, Zoya Yurkovetsky, Brian Nolen, Adele M. Marrangoni, Lydmila Velikokhatnaya, Andrzej Drukier, Steven Skates, Elieser Gorelik "Multimarker assay for early diagnosis of ovarian cancer" American Association for Cancer Research , v.47 , 2006 , p.653
K-H Kim, A Dobi, S Shaheduzzaman, CL Gao, K Masuda1, H Li, A Drukier, Y Gu, V Srikantan1, JS Rhim and S Srivastava "Characterization of the androgen receptor in a benign prostate tissue-derived human prostate epithelial cell line: RC-165N/human telomerase reverse transcriptase" Prostate Cancer and Prostatic Diseases , v.10 , 2007 , p.30
Ksenya Shchors, Elena Shchors, Fanya Rostker, Elizabeth R. Lawlor, Lamorna Brown-Swigart, and Gerard I. Evan "The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1b" GENES & DEVELOPMENT , v.20 , 2006 , p.2527
Oliver Kleiner, David A. Price, Natasha Ossetrova, Sergei Osetrov, Peter Volkovitsky, Andrzej K. Drukier, Jasminka Godovac-Zimmermann "Ultra-high sensitivity multi-photon detection imaging in proteomics analyses" Proteomics , v.5 , 2005 , p.2322
Richard Sainsbury, Andre Drukier, Natascha Ossetrova, John Tomaszewski, Jasminka Godovac-Zimmermann, Elena Schors "Ultra-sensitive immunoassays using multi-photon-detectionin diagnostic proteomics of blood" American Association for Cancer Research , v.47 , 2006 , p.2873

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