Award Abstract # 0321581
SBIR Phase II: New Convergent X-Ray Beam Based System for Protein Crystallography

NSF Org: TI
Translational Impacts
Recipient: X-RAY OPTICAL SYSTEMS, INC.
Initial Amendment Date: November 4, 2003
Latest Amendment Date: October 18, 2006
Award Number: 0321581
Award Instrument: Standard Grant
Program Manager: F.C. Thomas Allnutt
TI
 Translational Impacts
TIP
 Directorate for Technology, Innovation, and Partnerships
Start Date: December 1, 2003
End Date: November 30, 2007 (Estimated)
Total Intended Award Amount: $0.00
Total Awarded Amount to Date: $749,730.00
Funds Obligated to Date: FY 2004 = $499,903.00
FY 2006 = $249,827.00
History of Investigator:
  • Huapeng Huang (Principal Investigator)
    hhuang@xos.com
Recipient Sponsored Research Office: X-RAY OPTICAL SYSTEMS, INC.
15 TECH VALLEY DR STE 1
EAST GREENBUSH
NY  US  12061-4137
(518)880-1500
Sponsor Congressional District: 19
Primary Place of Performance: X-RAY OPTICAL SYSTEMS, INC.
15 TECH VALLEY DR STE 1
EAST GREENBUSH
NY  US  12061-4137
Primary Place of Performance
Congressional District:
19
Unique Entity Identifier (UEI): RZ1NGJXKHM23
Parent UEI: C81ZDK1LL4G7
NSF Program(s): SBIR Phase II
Primary Program Source: app-0104 
app-0106 
Program Reference Code(s): 9181, BIOT
Program Element Code(s): 537300
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.084

ABSTRACT


This Small Business Innovation Research (SBIR) Phase II project will develop a new convergent x-ray beam based crystallography system for measurement of the quality and the structure of protein crystals in an effort to support crystal growth development efforts and as a prescreening tool for very small protein crystals prior to refined, high-resolution structure determination at dedicated synchrotron-based macromolecular structure facilities. Measurements of a broad range of crystal types, sizes, and degrees of perfection will be carried out in an active protein crystal growth and characterization laboratory at the Wadsworth Center of the New York State Health Department. Parallel measurements using the same crystals will be made in this laboratory with a conventional state-of-the-art protein diffraction system in order to examine the potential benefits and limitations of the convergent beam method (CBM). Measurements will also be made in an industrial laboratory to evaluate the potential of CBM as a commercial, compact, high-intensity, low-power, low-cost, protein screening instrumentation.

The commercial application of this project will be in the area of structural proteomics. Development of a compact, high-efficiency, high-sensitivity system for measurement of the quality and preliminary structure of small protein crystals is crucial to implementation of the huge opportunities offered by recent advances in human and non-human genomics, with far-reaching consequences in the areas of disease therapy and drug discovery. Furthermore, such a system could find broad applications in academic, scientific and industrial programs for high- resolution microscopy of structure, texture, and
strain in metallurgical, geological, environmental and biological or other materials.

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